貨號	規(guī)格	價格	上海	北京	武漢	南京
S80047-1mg	99%	￥50.00 S80047-1mg ￥50.00 現(xiàn)貨	7 7	-	-	-
S80047-2mg	99%	￥80.00 S80047-2mg ￥80.00 現(xiàn)貨	4 4	-	-	-
S80047-5mg	99%	￥100.00 S80047-5mg ￥100.00 現(xiàn)貨	8 8	-	-	-
S80047-10mg	99%	￥180.00 S80047-10mg ￥180.00 現(xiàn)貨	6 6	-	-	-
S80047-50mg	99%	￥710.00 S80047-50mg ￥710.00 現(xiàn)貨	6 6	-	-	-
S80047-100mg	99%	￥1290.00 S80047-100mg ￥1290.00 2-3天	0 貨期：2-3天	-	-	-

大包裝詢價

加入購物車

產(chǎn)品介紹

Bemcentinib (R428) is a potent and selective inhibitor of Axl with an IC50 of 14 nM

產(chǎn)品描述：

Bemcentinib (R428) is a potent and selective inhibitor of Axl with an IC50 of 14 nM

靶點：

IC50: 14 nM (Axl kinase);TAMReceptor

體內(nèi)研究：

Bemcentinib (R428) (125 mg/kg, p.o.) significantly blocks MDA-MB-231-luc-D3H2LN metastases development in two independent mouse models of breast cancer dissemination, suppresses both tumor angiogenesis and vascular endothelial growth factor (VEGF)-induced corneal neovascularization in vivo. Bemcentinib (R428) (75 mg/kg/day, 25 mg/kg twice daily, p.o.) makes mice keep on a high-fat diet resulted in significantly reduced weight gain and subcutaneous and gonadal fat mass

參考文獻(xiàn)：

1. Sensi M, et al. Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase. J Invest Dermatol. 2011 Dec;131(12):2448-57. 2. Holland SJ, et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 2010 Feb 15;70(4):1544-54. 3. Lijnen HR, et al. Growth arrest-specific protein 6 receptor antagonism impairs adipocyte differentiation and adipose tissue development in mice. J Pharmacol Exp Ther. 2011 May;337(2):457-64.

溶解性：

DMSO : 25 mg/mL (49.34 mM; ultrasonic and warming and heat to 60°C)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.974 ml	9.869 ml	19.738 ml
5 mM	0.395 ml	1.974 ml	3.948 ml
10 mM	0.197 ml	0.987 ml	1.974 ml
50 mM	0.039 ml	0.197 ml	0.395 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

輸入產(chǎn)品批號：

如何獲取質(zhì)檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標(biāo)簽上如何找到貨號和批號?

摩爾濃度計算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計算重置

R428 (BGB324)